EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Competition propels, rather than limits, the success of low-affinity B cells in the germinal center response.
ジャーナル・号・ページ	Cell Rep, Vol. 44, Issue 2, Page 115334, Year 2025
掲載日	2025年2月15日
著者	Runhan Li / Keyan Bao / Can Liu / Xuejing Ma / Zhaolin Hua / Ping Zhu / Baidong Hou /
PubMed 要旨	The germinal center (GC) sets an environment where antigen-specific B cells are compelled to continuously increase their affinity to compete for the antigen and obtain Tfh help for survival and ...The germinal center (GC) sets an environment where antigen-specific B cells are compelled to continuously increase their affinity to compete for the antigen and obtain Tfh help for survival and propagation. Previous studies indicated that low-affinity B cells are disadvantaged in the presence of high-affinity ones, suggesting that competition may lead to the elimination of low-affinity B cells and their descendants. However, using a multivalent virus-mimicking antigen, our study demonstrates that low-affinity B cells not only successfully participate in GC responses alongside high-affinity B cells but also undergo accelerated affinity maturation under the more stringent competition. Furthermore, our cryo-electron-microscopy-based structural analysis reveals that both low-affinity and high-affinity B cells compete for the same antigenic epitope. Although the applicability of this idealized GC competition to true pathogen-induced responses remains uncertain, this change in perspective on the role of competition in low-affinity B cell evolution provides valuable insights for vaccine development.
リンク	Cell Rep / PubMed:39955776
手法	EM (単粒子)
解像度	2.8 - 4.3 Å
構造データ	37286 8w5d EMDB-37286, PDB-8w5d: Cryo-EM structure of Qb-Ab1 手法: EM (単粒子) / 解像度: 4.3 Å 37287 8w5e EMDB-37287, PDB-8w5e: Cryo-EM structure of Qb-Ab4 手法: EM (単粒子) / 解像度: 3.8 Å 37290 8w5f EMDB-37290, PDB-8w5f: Cryo-EM structure of Qb-Ab6 手法: EM (単粒子) / 解像度: 3.3 Å 37291 8w5g EMDB-37291, PDB-8w5g: Cryo-EM structure of Qb-Ab7 手法: EM (単粒子) / 解像度: 4.0 Å 37292 8w5h EMDB-37292, PDB-8w5h: Cryo-EM structure of Qb-Ab10 手法: EM (単粒子) / 解像度: 2.8 Å 37293 8w5i EMDB-37293, PDB-8w5i: Cryo-EM structure of Qb-Ab14 手法: EM (単粒子) / 解像度: 3.6 Å 37296 8w5l EMDB-37296, PDB-8w5l: Cryo-EM structure of Qb-Ab16 手法: EM (単粒子) / 解像度: 2.8 Å 37297 8w5m EMDB-37297, PDB-8w5m: Cryo-EM structure of Qb-Ab17 手法: EM (単粒子) / 解像度: 3.1 Å 37298 8w5n EMDB-37298, PDB-8w5n: Cryo-EM structure of Qb-Ab21 手法: EM (単粒子) / 解像度: 3.1 Å 37299 8w5o EMDB-37299, PDB-8w5o: Cryo-EM structure of Qb-Ab31 手法: EM (単粒子) / 解像度: 3.6 Å 37300 8w5p EMDB-37300, PDB-8w5p: Cryo-EM structure of Qb-Ab40 手法: EM (単粒子) / 解像度: 3.3 Å 37301 8w5q EMDB-37301, PDB-8w5q: Cryo-EM structure of Qb-Ab45 手法: EM (単粒子) / 解像度: 4.1 Å 37302 8w5r EMDB-37302, PDB-8w5r: Cryo-EM structure of Qb-Ab53 手法: EM (単粒子) / 解像度: 3.1 Å 37303 8w5t EMDB-37303, PDB-8w5t: Cryo-EM structure of Qb-Ab57 手法: EM (単粒子) / 解像度: 3.6 Å 37304 8w5u EMDB-37304, PDB-8w5u: Cryo-EM structure of QbN10F-Ab40 手法: EM (単粒子) / 解像度: 3.9 Å 37305 8w5v EMDB-37305, PDB-8w5v: Cryo-EM structure of QbN10K-Ab40 手法: EM (単粒子) / 解像度: 3.4 Å 37306 8w5w EMDB-37306, PDB-8w5w: Cryo-EM structure of Qb-Ab8 手法: EM (単粒子) / 解像度: 3.3 Å
由来	mus musculus (ハツカネズミ) escherichia phage qbeta (ファージ) Mus (ネズミ)
キーワード	IMMUNE SYSTEM / Qb / cryo-EM / Antibody