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-Structure paper
Title | Structure-Based Optimization of Selective and Brain Penetrant CK1 delta Inhibitors for the Treatment of Circadian Disruptions. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 15, Page 486-492, Year 2024 |
Publish date | Feb 4, 2024 (structure data deposition date) |
Authors | McCarver, S. / Hanna, L. / Samant, A. / Thompson, A.A. / Seierstad, M. / Saha, A. / Wu, D. / Lord, B. / Sutton, S.W. / Shah, V. ...McCarver, S. / Hanna, L. / Samant, A. / Thompson, A.A. / Seierstad, M. / Saha, A. / Wu, D. / Lord, B. / Sutton, S.W. / Shah, V. / Milligan, C.M. / Wennerholm, M. / Shelton, J. / Lebold, T.P. / Shireman, B.T. |
External links | Acs Med. Chem. Lett. / PubMed:38628796 |
Methods | X-ray diffraction |
Resolution | 1.85 - 2.47 Å |
Structure data | PDB-8vxd: PDB-8vxe: PDB-8vxf: |
Chemicals | PDB-1ad7: ChemComp-HOH: PDB-1ad9: PDB-1ad8: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / CK1D / KINASE / TRANSFERASE / inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex / p38 alpha / MAPK14 |