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TitleHigh-resolution snapshots of the talin auto-inhibitory states suggest roles in cell adhesion and signaling.
Journal, issue, pagesNat Commun, Vol. 15, Issue 1, Page 9270, Year 2024
Publish dateOct 28, 2024
AuthorsErumbi S Rangarajan / Julian L Bois / Scott B Hansen / Tina Izard /
PubMed AbstractTalin regulates crucial cellular functions, including cell adhesion and motility, and affects human diseases. Triggered by mechanical forces, talin plays crucial roles in facilitating the formation ...Talin regulates crucial cellular functions, including cell adhesion and motility, and affects human diseases. Triggered by mechanical forces, talin plays crucial roles in facilitating the formation of focal adhesions and recruiting essential focal adhesion regulatory elements such as vinculin. The structural flexibility allows talin to fine-tune its signaling responses. This study presents our 2.7 Å cryoEM structures of talin, which surprisingly uncovers several auto-inhibitory states. Contrary to previous suggestions, our structures reveal that (1) the first and last three domains are not involved in maintaining talin in its closed state and are mobile, (2) the talin F-actin and membrane binding domain are loosely attached and thus available for binding, and (3) the main force-sensing domain is oriented with its vinculin binding sites ready for release. These structural snapshots offer insights and advancements in understanding the dynamic talin activation mechanism, which is crucial for mediating cell adhesion.
External linksNat Commun / PubMed:39468080 / PubMed Central
MethodsEM (single particle)
Resolution2.7 - 5.5 Å
Structure data

43152

8vdo

EMDB-43152, PDB-8vdo:
Cryogenic electron microscopy model of full-length talin lacking F2, R12 and FABD.
Method: EM (single particle) / Resolution: 2.7 Å

43154

8vdp

EMDB-43154, PDB-8vdp:
Cryogenic electron microscopy model of full-length talin without FABD
Method: EM (single particle) / Resolution: 3.4 Å

43155

8vdq

EMDB-43155, PDB-8vdq:
Cryogenic electron microscopy model of full-length talin
Method: EM (single particle) / Resolution: 5.5 Å

43156

8vdr

EMDB-43156, PDB-8vdr:
Cryogenic electron microscopy model of full-length talin without R12 and FABD
Method: EM (single particle) / Resolution: 3.7 Å

EMDB-44931: Cryogenic electron microscopy model of talin with alternate FABD conformation
Method: EM (single particle) / Resolution: 3.4 Å

Source
  • mus musculus (house mouse)
KeywordsCELL ADHESION / Talin / focal adhesion / f-actin binding

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