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-Structure paper
Title | Discovery of Pyridopyrimidinones that Selectively Inhibit the H1047R PI3K alpha Mutant Protein. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 4936-4949, Year 2024 |
Publish date | Dec 5, 2023 (structure data deposition date) |
Authors | Ketcham, J.M. / Harwood, S.J. / Aranda, R. / Aloiau, A.N. / Bobek, B.M. / Briere, D.M. / Burns, A.C. / Caddell Haatveit, K. / Calinisan, A. / Clarine, J. ...Ketcham, J.M. / Harwood, S.J. / Aranda, R. / Aloiau, A.N. / Bobek, B.M. / Briere, D.M. / Burns, A.C. / Caddell Haatveit, K. / Calinisan, A. / Clarine, J. / Elliott, A. / Engstrom, L.D. / Gunn, R.J. / Ivetac, A. / Jones, B. / Kuehler, J. / Lawson, J.D. / Nguyen, N. / Parker, C. / Pearson, K.E. / Rahbaek, L. / Saechao, B. / Wang, X. / Waters, A. / Waters, L. / Watkins, A.H. / Olson, P. / Smith, C.R. / Christensen, J.G. / Marx, M.A. |
External links | J. Med. Chem. / PubMed:38477582 |
Methods | X-ray diffraction |
Resolution | 2.61 - 3.58 Å |
Structure data | PDB-8v8h: PDB-8v8i: PDB-8v8j: PDB-8v8u: PDB-8v8v: |
Chemicals |
ChemComp-YO4:
ChemComp-YNZ:
ChemComp-YOR: ChemComp-CL: ChemComp-HOH: ChemComp-1LT:
ChemComp-YQB:
ChemComp-YQ2: |
Source |
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Keywords | SIGNALING PROTEIN / H1047R / PI3K / PI3Ka |