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-Structure paper
Title | Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 3112-3126, Year 2024 |
Publish date | Nov 2, 2023 (structure data deposition date) |
Authors | Hummel, J.R. / Xiao, K.J. / Yang, J.C. / Epling, L.B. / Mukai, K. / Ye, Q. / Xu, M. / Qian, D. / Huo, L. / Weber, M. ...Hummel, J.R. / Xiao, K.J. / Yang, J.C. / Epling, L.B. / Mukai, K. / Ye, Q. / Xu, M. / Qian, D. / Huo, L. / Weber, M. / Roman, V. / Lo, Y. / Drake, K. / Stump, K. / Covington, M. / Kapilashrami, K. / Zhang, G. / Ye, M. / Diamond, S. / Yeleswaram, S. / Macarron, R. / Deller, M.C. / Wee, S. / Kim, S. / Wang, X. / Wu, L. / Yao, W. |
External links | J. Med. Chem. / PubMed:38325398 |
Methods | X-ray diffraction |
Resolution | 1.55 Å |
Structure data | PDB-8uv0: |
Chemicals |
ChemComp-XKU: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/INHIBITOR / CDK2 / serine/threonine kinase / cell cycle regulation / aminopyrimidine / inhibitor / TRANSFERASE / TRANSFERASE-INHIBITOR complex |