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TitlePreclinical proof of principle for orally delivered Th17 antagonist miniproteins.
Journal, issue, pagesCell, Vol. 187, Page 4305-, Year 2024
Publish dateOct 31, 2023 (structure data deposition date)
AuthorsBerger, S. / Seeger, F. / Yu, T.Y. / Aydin, M. / Yang, H. / Rosenblum, D. / Guenin-Mace, L. / Glassman, C. / Arguinchona, L. / Sniezek, C. ...Berger, S. / Seeger, F. / Yu, T.Y. / Aydin, M. / Yang, H. / Rosenblum, D. / Guenin-Mace, L. / Glassman, C. / Arguinchona, L. / Sniezek, C. / Blackstone, A. / Carter, L. / Ravichandran, R. / Ahlrichs, M. / Murphy, M. / Pultz, I.S. / Kang, A. / Bera, A.K. / Stewart, L. / Garcia, K.C. / Naik, S. / Spangler, J.B. / Beigel, F. / Siebeck, M. / Gropp, R. / Baker, D.
External linksCell / PubMed:38936360
MethodsX-ray diffraction
Resolution1.94 Å
Structure data

PDB-8utk:
IL-23R minibinder - 23R-B04dslf02IB
Method: X-RAY DIFFRACTION / Resolution: 1.94 Å

Chemicals

ChemComp-PG6:
1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE

ChemComp-SO4:
SULFATE ION

ChemComp-PG5:
1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
KeywordsDE NOVO PROTEIN / Computational design / selective inhibitors / IL-2 IL-17 cytokines DE NOVO PROTEIN

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