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Title | Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 6456-6494, Year 2024 |
Publish date | Oct 29, 2023 (structure data deposition date) |
Authors | Ramos, A.L. / Goedken, E.R. / Frank, K.E. / Argiriadi, M.A. / Bazzaz, S. / Bian, Z. / Brown, J.T.C. / Centrella, P.A. / Chen, H.J. / Disch, J.S. ...Ramos, A.L. / Goedken, E.R. / Frank, K.E. / Argiriadi, M.A. / Bazzaz, S. / Bian, Z. / Brown, J.T.C. / Centrella, P.A. / Chen, H.J. / Disch, J.S. / Donner, P.L. / Duignan, D.B. / Gikunju, D. / Greszler, S.N. / Guie, M.A. / Habeshian, S. / Hartl, H.E. / Hein, C.D. / Hutchins, C.W. / Jetson, R. / Keefe, A.D. / Khan, H. / Li, H.Q. / Olszewski, A. / Ortiz Cardona, B.J. / Osuma, A. / Panchal, S.C. / Phelan, R. / Qiu, W. / Shotwell, J.B. / Shrestha, A. / Srikumaran, M. / Su, Z. / Sun, C. / Upadhyay, A.K. / Wood, M.D. / Wu, H. / Zhang, R. / Zhang, Y. / Zhao, G. / Zhu, H. / Webster, M.P. |
External links | J. Med. Chem. / PubMed:38574366 |
Methods | X-ray diffraction |
Resolution | 1.47 - 1.83 Å |
Structure data | PDB-8usr: PDB-8uss: |
Chemicals |
ChemComp-XCE: ChemComp-HOH:
ChemComp-XCW: ChemComp-CL: |
Source |
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Keywords | CYTOKINE / Homodimer / inhibitor / DEL |