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-Structure paper
Title | TKB272, an Orally Available SARS-CoV-2-Mpro Inhibitor Containing 5-Fluorobenzothiazole, Potently Blocks SARS-CoV-2 Replication without Ritonavir |
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Journal, issue, pages | To Be Published |
Publish date | Oct 6, 2023 (structure data deposition date) |
![]() | Higashi-Kuwata, N. / Bulut, H. / Hayashi, H. / Tsuji, K. / Ogata-Aoki, H. / Kiso, M. / Takamune, N. / Kishimoto, N. / Hattori, S. / Ishii, T. ...Higashi-Kuwata, N. / Bulut, H. / Hayashi, H. / Tsuji, K. / Ogata-Aoki, H. / Kiso, M. / Takamune, N. / Kishimoto, N. / Hattori, S. / Ishii, T. / Kobayakawa, T. / Nakano, K. / Das, D. / Saruwatari, J. / Hasegawa, K. / Murayama, K. / Sukenaga, Y. / Takamatsu, Y. / Yoshimura, K. / Aoki, M. / Okamura, T. / Yamayoshi, S. / Kawaoka, Y. / Misumi, S. / Tamamura, H. / Mitsuya, H. |
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Methods | X-ray diffraction |
Resolution | 1.74 - 2.067 Å |
Structure data | ![]() PDB-8uh5: ![]() PDB-8uh8: ![]() PDB-8uh9: |
Chemicals | ![]() ChemComp-WOK: ![]() ChemComp-PEG: ![]() ChemComp-HOH: |
Source |
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![]() | VIRAL PROTEIN / SARS-CoV-2 main protease / 3C-like proteinase / SARS-CoV-2 |