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-Structure paper
Title | Development of a new class of potent and highly selective G protein-coupled receptor kinase 5 inhibitors and structural insight from crystal structures of inhibitor complexes. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 264, Page 115931-115931, Year 2023 |
Publish date | Sep 21, 2023 (structure data deposition date) |
Authors | Chen, Y. / Sonawane, A. / Manda, R. / Gadi, R.K. / Tesmer, J.J.G. / Ghosh, A.K. |
External links | Eur. J. Med. Chem. / PubMed:38016297 |
Methods | X-ray diffraction |
Resolution | 2.5 - 2.8 Å |
Structure data | PDB-8uap: PDB-8uaq: |
Chemicals | ChemComp-W2T: ChemComp-HOH: ChemComp-W3F: |
Source |
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Keywords | SIGNALING PROTEIN/INHIBITOR / G protein-coupled receptor / GPCR G protein-coupled receptor kinase / GRK kinase / SIGNALING PROTEIN-INHIBITOR complex |