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-Structure paper
Title | Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability. |
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Journal, issue, pages | Mabs, Vol. 16, Page 2309685-2309685, Year 2024 |
Publish date | Sep 7, 2023 (structure data deposition date) |
Authors | Liang, W.C. / Xi, H. / Sun, D. / D'Ascenzo, L. / Zarzar, J. / Stephens, N. / Cook, R. / Li, Y. / Ye, Z. / Matsumoto, M. ...Liang, W.C. / Xi, H. / Sun, D. / D'Ascenzo, L. / Zarzar, J. / Stephens, N. / Cook, R. / Li, Y. / Ye, Z. / Matsumoto, M. / Payandeh, J. / Masureel, M. / Wu, Y. |
External links | Mabs / PubMed:38356181 |
Methods | X-ray diffraction |
Resolution | 2.51 - 2.73 Å |
Structure data | PDB-8u31: PDB-8u32: |
Chemicals | ChemComp-GOL: ChemComp-HOH: ChemComp-NAG: |
Source |
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Keywords | STRUCTURAL PROTEIN/IMMUNE SYSTEM / PD-1 / Fab / STRUCTURAL PROTEIN / STRUCTURAL PROTEIN-IMMUNE SYSTEM complex |