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TitleInhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs.
Journal, issue, pagesJ Immunol., Vol. 212, Page 689-701, Year 2024
Publish dateAug 25, 2023 (structure data deposition date)
AuthorsXu, X. / Herdendorf, T.J. / Duan, H. / Rohlik, D.L. / Roy, S. / Zhou, H. / Alkhateeb, H. / Khandelwal, S. / Zhou, Q. / Li, P. ...Xu, X. / Herdendorf, T.J. / Duan, H. / Rohlik, D.L. / Roy, S. / Zhou, H. / Alkhateeb, H. / Khandelwal, S. / Zhou, Q. / Li, P. / Arepally, G.M. / Walker, J.K. / Garcia, B.L. / Geisbrecht, B.V.
External linksJ Immunol. / PubMed:38149922
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-8typ:
Complement Protease C1s Inhibited by 6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-SQT:
6-(4-phenylpiperazin-1-yl)pyridine-3-carboximidamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / complement / protease / inhibitor

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