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-Structure paper
| Title | Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation. |
|---|---|
| Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 121, Page e2307086120-e2307086120, Year 2024 |
| Publish date | Aug 24, 2023 (structure data deposition date) |
 Authors | Babbe, H. / Sundberg, T.B. / Tichenor, M. / Seierstad, M. / Bacani, G. / Berstler, J. / Chai, W. / Chang, L. / Chung, M. / Coe, K. ...Babbe, H. / Sundberg, T.B. / Tichenor, M. / Seierstad, M. / Bacani, G. / Berstler, J. / Chai, W. / Chang, L. / Chung, M. / Coe, K. / Collins, B. / Finley, M. / Guletsky, A. / Lemke, C.T. / Mak, P.A. / Mathur, A. / Mercado-Marin, E.V. / Metkar, S. / Raymond, D.D. / Rives, M.L. / Rizzolio, M. / Shaffer, P.L. / Smith, R. / Smith, J. / Steele, R. / Steffens, H. / Suarez, J. / Tian, G. / Majewski, N. / Volak, L.P. / Wei, J. / Desai, P.T. / Ong, L.L. / Koudriakova, T. / Goldberg, S.D. / Hirst, G. / Kaushik, V.K. / Ort, T. / Seth, N. / Graham, D.B. / Plevy, S. / Venable, J.D. / Xavier, R.J. / Towne, J.E. |
 External links | Proc. Natl. Acad. Sci. USA / PubMed:38147543 |
| Methods | X-ray diffraction |
| Resolution | 2.1 Å |
| Structure data |  PDB-8txy: |
| Chemicals |  ChemComp-PEG:  ChemComp-SJ0:  ChemComp-SO4:  ChemComp-HOH: |
| Source |
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 Keywords | BIOSYNTHETIC PROTEIN / Kinase / enzyme / chimera / inhibitor |
homo sapiens (human)