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-Structure paper
Title | A Tiny Pocket Packs a Punch: Leveraging Pyridones for the Discovery of CNS-Penetrant Aza-indazole IRAK4 Inhibitors. |
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Journal, issue, pages | Acs Med. Chem. Lett., Vol. 15, Page 714-721, Year 2024 |
Publish date | Aug 18, 2023 (structure data deposition date) |
Authors | Bolduc, P.N. / Pfaffenbach, M. / Evans, R. / Xin, Z. / Henry, K.L. / Gao, F. / Fang, T. / Silbereis, J. / Vera Rebollar, J. / Li, P. ...Bolduc, P.N. / Pfaffenbach, M. / Evans, R. / Xin, Z. / Henry, K.L. / Gao, F. / Fang, T. / Silbereis, J. / Vera Rebollar, J. / Li, P. / Chodaparambil, J.V. / Metrick, C. / Peterson, E.A. |
External links | Acs Med. Chem. Lett. / PubMed:38746903 |
Methods | X-ray diffraction |
Resolution | 1.95 - 2.1 Å |
Structure data | PDB-8tvm: PDB-8tvn: |
Chemicals |
ChemComp-VDC: ChemComp-HOH:
ChemComp-VE9: |
Source |
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Keywords | TRANSFERASE/INHIBITOR / kinase / TRANSFERASE / TRANSFERASE-INHIBITOR complex |