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-Structure paper
Title | Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket. |
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Journal, issue, pages | Cell, Year 2024 |
Publish date | Jul 27, 2023 (structure data deposition date) |
Authors | Morstein, J. / Bowcut, V. / Fernando, M. / Yang, Y. / Zhu, L. / Jenkins, M.L. / Evans, J.T. / Guiley, K.Z. / Peacock, D.M. / Krahnke, S. ...Morstein, J. / Bowcut, V. / Fernando, M. / Yang, Y. / Zhu, L. / Jenkins, M.L. / Evans, J.T. / Guiley, K.Z. / Peacock, D.M. / Krahnke, S. / Lin, Z. / Taran, K.A. / Huang, B.J. / Stephen, A.G. / Burke, J.E. / Lightstone, F.C. / Shokat, K.M. |
External links | Cell / PubMed:39255801 |
Methods | X-ray diffraction |
Resolution | 1.70003947485 Å |
Structure data | PDB-8tlr: |
Chemicals | ChemComp-GDP: ChemComp-MOV: ChemComp-MG: ChemComp-HOH: |
Source |
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Keywords | ONCOPROTEIN / HRAS / H-Ras / sotorasib / Ras |