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-Structure paper
Title | STX-478, a Mutant-Selective, Allosteric PI3K alpha Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3K alpha-Mutant Xenografts. |
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Journal, issue, pages | Cancer Discov, Vol. 13, Page 2432-2447, Year 2023 |
Publish date | Jul 5, 2023 (structure data deposition date) |
![]() | Buckbinder, L. / St Jean Jr., D.J. / Tieu, T. / Ladd, B. / Hilbert, B. / Wang, W. / Alltucker, J.T. / Manimala, S. / Kryukov, G.V. / Brooijmans, N. ...Buckbinder, L. / St Jean Jr., D.J. / Tieu, T. / Ladd, B. / Hilbert, B. / Wang, W. / Alltucker, J.T. / Manimala, S. / Kryukov, G.V. / Brooijmans, N. / Dowdell, G. / Jonsson, P. / Huff, M. / Guzman-Perez, A. / Jackson, E.L. / Goncalves, M.D. / Stuart, D.D. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.928 - 3.11 Å |
Structure data | ![]() PDB-8tdu: ![]() PDB-8tgd: |
Chemicals | ![]() ChemComp-X3N: ![]() ChemComp-ZWE: ![]() ChemComp-HOH: ![]() ChemComp-EDO: |
Source |
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![]() | TRANSFERASE/TRANSFERASE INHIBITOR / Kinase / Inhibitor / TRANSFERASE / TRANSFERASE-TRANSFERASE INHIBITOR complex / TRANSFERASE/TRANSFERSE INHIBITOR / TRANSFERASE-TRANSFERSE INHIBITOR complex |