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-Structure paper
Title | Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 774-781, Year 2024 |
Publish date | Jun 13, 2023 (structure data deposition date) |
![]() | Smith, C.R. / Chen, D. / Christensen, J.G. / Coulombe, R. / Fethiere, J. / Gunn, R.J. / Hollander, J. / Jones, B. / Ketcham, J.M. / Khare, S. ...Smith, C.R. / Chen, D. / Christensen, J.G. / Coulombe, R. / Fethiere, J. / Gunn, R.J. / Hollander, J. / Jones, B. / Ketcham, J.M. / Khare, S. / Kuehler, J. / Lawson, J.D. / Marx, M.A. / Olson, P. / Pearson, K.E. / Ren, C. / Tsagris, D. / Ulaganathan, T. / Van't Veer, I. / Wang, X. / Ivetac, A. |
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Methods | X-ray diffraction |
Resolution | 1.6 - 2.73 Å |
Structure data | ![]() PDB-8t5g: ![]() PDB-8t5m: ![]() PDB-8t5r: ![]() PDB-8uc9: ![]() PDB-8uf2: ![]() PDB-8uh0: |
Chemicals | ![]() ChemComp-DMS: ![]() ChemComp-SO4: ![]() ChemComp-THA: ![]() ChemComp-HOH: ![]() ChemComp-EDO: ![]() ChemComp-YIF: ![]() ChemComp-6LH: ![]() ChemComp-QBC: ![]() ChemComp-WRN: |
Source |
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![]() | SIGNALING PROTEIN / SOS2 / Nucleotide Exchange Factor / GEF / KRAS / RAS / Fragment screening / FBLD |