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Structure paper

TitleRapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining.
Journal, issue, pagesNat Commun, Vol. 15, Page 8382-8382, Year 2024
Publish dateJun 12, 2023 (structure data deposition date)
AuthorsHsiao, Y.C. / Wallweber, H.A. / Alberstein, R.G. / Lin, Z. / Du, C. / Etxeberria, A. / Aung, T. / Shang, Y. / Seshasayee, D. / Seeger, F. ...Hsiao, Y.C. / Wallweber, H.A. / Alberstein, R.G. / Lin, Z. / Du, C. / Etxeberria, A. / Aung, T. / Shang, Y. / Seshasayee, D. / Seeger, F. / Watkins, A.M. / Hansen, D.V. / Bohlen, C.J. / Hsu, P.L. / Hotzel, I.
External linksNat Commun / PubMed:39333507
MethodsX-ray diffraction
Resolution1.9 - 2 Å
Structure data

PDB-8t51:
Crystal structure of Fab 3.10C2 bound to TREM2
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-8t59:
Crystal structure of Para.09 bound to TREM2
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-ZN:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-ACT:
ACETATE ION

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsPEPTIDE BINDING PROTEIN / Antibody / Fab / IMMUNE SYSTEM/PEPTIDE BINDING PROTEIN / complex / antigen / IMMUNE SYSTEM-PEPTIDE BINDING PROTEIN complex

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