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-Structure paper
Title | Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease. |
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Journal, issue, pages | Nat Commun, Vol. 15, Page 3883-3883, Year 2024 |
Publish date | May 2, 2023 (structure data deposition date) |
![]() | D'Ordine, A.M. / Jogl, G. / Sedivy, J.M. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.83 - 2.23 Å |
Structure data | ![]() PDB-8sp5: ![]() PDB-8sp7: |
Chemicals | ![]() ChemComp-MN: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-AMH: |
Source |
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![]() | HYDROLASE / LINE-1 retrotransposon / endonuclease / metal ion complex / fragment screening / small molecule complex |