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Title | Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity. |
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Journal, issue, pages | JCI Insight, Vol. 9, Year 2024 |
Publish date | Apr 30, 2023 (structure data deposition date) |
Authors | Leonard, E.K. / Tomala, J. / Gould, J.R. / Leff, M.I. / Lin, J.X. / Li, P. / Porter, M.J. / Johansen, E.R. / Thompson, L. / Cao, S.D. ...Leonard, E.K. / Tomala, J. / Gould, J.R. / Leff, M.I. / Lin, J.X. / Li, P. / Porter, M.J. / Johansen, E.R. / Thompson, L. / Cao, S.D. / Hou, S. / Henclova, T. / Huliciak, M. / Sargunas, P.R. / Fabilane, C.S. / Vanek, O. / Kovar, M. / Schneider, B. / Raimondi, G. / Leonard, W.J. / Spangler, J.B. |
External links | JCI Insight / PubMed:39115939 |
Methods | X-ray diffraction |
Resolution | 1.64 - 1.71 Å |
Structure data | PDB-8sow: PDB-8soz: |
Chemicals | ChemComp-HOH: |
Source |
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Keywords | CYTOKINE / Complex / Antibody / Interleukin |