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TitleEnhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions.
Journal, issue, pagesJ Immunother Cancer, Vol. 11, Year 2023
Publish dateApr 29, 2023 (structure data deposition date)
AuthorsLameris, R. / Shahine, A. / Veth, M. / Westerman, B. / Godfrey, D.I. / Lutje Hulsik, D. / Brouwer, P. / Rossjohn, J. / de Gruijl, T.D. / van der Vliet, H.J.
External linksJ Immunother Cancer / PubMed:38040419
MethodsX-ray diffraction
Resolution2.33 Å
Structure data

PDB-8sos:
Human CD1d presenting sphingomyelin C24:1 in complex with VHH nanobody 1D17
Method: X-RAY DIFFRACTION / Resolution: 2.33 Å

Chemicals

ChemComp-FO4:
sphingomyelin

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsIMMUNE SYSTEM / CD1d / sphingomyelin / NKT / nanobody / VHH / 1D17

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