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Title | Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRAS G12C Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 67, Page 11024-11052, Year 2024 |
Publish date | Mar 6, 2024 (structure data deposition date) |
Authors | Ma, X. / Sloman, D.L. / Duggal, R. / Anderson, K.D. / Ballard, J.E. / Bharathan, I. / Brynczka, C. / Gathiaka, S. / Henderson, T.J. / Lyons, T.W. ...Ma, X. / Sloman, D.L. / Duggal, R. / Anderson, K.D. / Ballard, J.E. / Bharathan, I. / Brynczka, C. / Gathiaka, S. / Henderson, T.J. / Lyons, T.W. / Miller, R. / Munsell, E.V. / Orth, P. / Otte, R.D. / Palani, A. / Rankic, D.A. / Robinson, M.R. / Sather, A.C. / Solban, N. / Song, X.S. / Wen, X. / Xu, Z. / Yang, Y. / Yang, R. / Day, P.J. / Stoeck, A. / Bennett, D.J. / Han, Y. |
External links | J. Med. Chem. / PubMed:38924388 |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | PDB-8s8c: |
Chemicals | ChemComp-GDP: ChemComp-MG: PDB-1h5u: ChemComp-HOH: |
Source |
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Keywords | SIGNALING PROTEIN / Nucleotide Binding / GTPase / Hydrolase / Signal Transduction |