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Structure paper

TitleHuman 2'-Deoxynucleoside 5'-Phosphate N-Hydrolase 1: The Catalytic Roles of Tyr24 and Asp80.
Journal, issue, pagesChembiochem, Vol. 25, Page e202400047-e202400047, Year 2024
Publish dateJan 17, 2024 (structure data deposition date)
AuthorsCarberry, A.E. / Devi, S. / Harrison, D.J. / da Silva, R.G.
External linksChembiochem / PubMed:38350003
MethodsX-ray diffraction
Resolution1.75 - 2.14 Å
Structure data

PDB-8rps:
Crystal structure of human DNPH1 mutant- D80N bound to 5hmdUMP
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-8rpt:
Crystal structure of human DNPH1 mutant- D80A
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-8rqd:
Crystal structure of human DNPH1 mutant-Y24F
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

Chemicals

ChemComp-5HU:
5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsHYDROLASE / deoxyribonucleoside 5'-monophosphate N-glycosidase activity

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