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TitleThe Arthropoda-specific Tramtrack group BTB protein domains use previously unknown interface to form hexamers.
Journal, issue, pagesElife, Vol. 13, Year 2024
Publish dateSep 2, 2024
AuthorsArtem N Bonchuk / Konstantin I Balagurov / Rozbeh Baradaran / Konstantin M Boyko / Nikolai N Sluchanko / Anastasia M Khrustaleva / Anna D Burtseva / Olga V Arkova / Karina K Khalisova / Vladimir O Popov / Andreas Naschberger / Pavel G Georgiev /
PubMed AbstractBTB (bric-a-brack, Tramtrack, and broad complex) is a diverse group of protein-protein interaction domains found within metazoan proteins. Transcription factors contain a dimerizing BTB subtype with ...BTB (bric-a-brack, Tramtrack, and broad complex) is a diverse group of protein-protein interaction domains found within metazoan proteins. Transcription factors contain a dimerizing BTB subtype with a characteristic N-terminal extension. The Tramtrack group (TTK) is a distinct type of BTB domain, which can multimerize. Single-particle cryo-EM microscopy revealed that the TTK-type BTB domains assemble into a hexameric structure consisting of three canonical BTB dimers connected through a previously uncharacterized interface. We demonstrated that the TTK-type BTB domains are found only in Arthropods and have undergone lineage-specific expansion in modern insects. The genome encodes 24 transcription factors with TTK-type BTB domains, whereas only four have non-TTK-type BTB domains. Yeast two-hybrid analysis revealed that the TTK-type BTB domains have an unusually broad potential for heteromeric associations presumably through a dimer-dimer interaction interface. Thus, the TTK-type BTB domains are a structurally and functionally distinct group of protein domains specific to Arthropodan transcription factors.
External linksElife / PubMed:39221775 / PubMed Central
MethodsEM (single particle)
Resolution3.3 Å
Structure data

19049

8rc6

EMDB-19049, PDB-8rc6:
Cryo-EM structure of hexameric BTB domain of Drosophila CG6765 protein
Method: EM (single particle) / Resolution: 3.3 Å

Source
  • drosophila melanogaster (fruit fly)
KeywordsTRANSCRIPTION / DNA-binding / transcription regulation / oligomerization

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