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TitleP-Stereodefined morpholino dinucleoside 3',5'-phosphorothioates.
Journal, issue, pagesOrg. Biomol. Chem., Vol. 22, Page 8737-8742, Year 2024
Publish dateNov 17, 2023 (structure data deposition date)
AuthorsJastrzebska, K. / Antonczyk, P. / Dolot, R.
External linksOrg. Biomol. Chem. / PubMed:39392463
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-8r5v:
Crystal structure of bovine pancreatic ribonuclease A in complex with [Sp-PS]-mU-dT dinucleotide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-Y4I:
1-[(2~{R},4~{S},5~{R})-5-[[[(2~{R},6~{S})-2-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-6-(hydroxymethyl)morpholin-4-yl]-oxidanyl-phosphinothioyl]oxymethyl]-4-oxidanyl-oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione

ChemComp-TF4:
DICHLORO-ACETIC ACID

ChemComp-HOH:
WATER

Source
  • bos taurus (domestic cattle)
KeywordsHYDROLASE / complex / dinucleotide / inhibitor / ribonuclease / RNase

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