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TitleA broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites.
Journal, issue, pagesNat Commun, Vol. 15, Page 7206-7206, Year 2024
Publish dateOct 14, 2023 (structure data deposition date)
AuthorsAngage, D. / Chmielewski, J. / Maddumage, J.C. / Hesping, E. / Caiazzo, S. / Lai, K.H. / Yeoh, L.M. / Menassa, J. / Opi, D.H. / Cairns, C. ...Angage, D. / Chmielewski, J. / Maddumage, J.C. / Hesping, E. / Caiazzo, S. / Lai, K.H. / Yeoh, L.M. / Menassa, J. / Opi, D.H. / Cairns, C. / Puthalakath, H. / Beeson, J.G. / Kvansakul, M. / Boddey, J.A. / Wilson, D.W. / Anders, R.F. / Foley, M.
External linksNat Commun / PubMed:39174515
MethodsX-ray diffraction
Resolution2.6 - 3 Å
Structure data

PDB-8qu7:
Crystal structure of the Plasmodium falciparum Apical membrane antigen (AMA1) in complex with single domain i-body WD34
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-8qus:
Crystal structure of the Plasmodium vivax Apical membrane antigen (AMA1) in complex with single domain i-body WD34
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • plasmodium falciparum 3d7 (eukaryote)
  • homo sapiens (human)
  • plasmodium vivax sal-1 (eukaryote)
KeywordsPROTEIN BINDING / Plasmodium / AMA1 / i-body

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