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TitleDevelopment of Potent Mcl-1 Inhibitors: Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 3039-3065, Year 2024
Publish dateOct 10, 2023 (structure data deposition date)
AuthorsHekking, K.F.W. / Maroto, S. / van Kekem, K. / Haasjes, F.S. / Slootweg, J.C. / Oude Alink, P.G.B. / Dirks, R. / Sardana, M. / Bolster, M.G. / Kuijpers, B. ...Hekking, K.F.W. / Maroto, S. / van Kekem, K. / Haasjes, F.S. / Slootweg, J.C. / Oude Alink, P.G.B. / Dirks, R. / Sardana, M. / Bolster, M.G. / Kuijpers, B. / Smith, D. / Doodeman, R. / Scheepstra, M. / Zech, B. / Mulvihill, M. / Renzetti, L.M. / Babiss, L. / Centrella, P.A. / Clark, M.A. / Cuozzo, J.W. / Guie, M.A. / Sigel, E. / Habeshian, S. / Hupp, C.D. / Liu, J. / Thomson, H.A. / Zhang, Y. / Keefe, A.D. / Muller, G. / Gremmen, S.
External linksJ. Med. Chem. / PubMed:38306405
MethodsX-ray diffraction
Resolution2.106 Å
Structure data

PDB-8qso:
Crystal structure of human Mcl-1 in complex with compound 1
Method: X-RAY DIFFRACTION / Resolution: 2.106 Å

Chemicals


ChemComp, No image

ChemComp-WXW:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Mcl-1 / Inhibitor

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