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Title | Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators. |
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Journal, issue, pages | Eur. J. Med. Chem., Vol. 264, Page 116036-116036, Year 2023 |
Publish date | Sep 1, 2023 (structure data deposition date) |
Authors | Francotte, P. / Bay, Y. / Goffin, E. / Colson, T. / Lesenfants, C. / Dorosz, J. / Laulumaa, S. / Fraikin, P. / de Tullio, P. / Beaufour, C. ...Francotte, P. / Bay, Y. / Goffin, E. / Colson, T. / Lesenfants, C. / Dorosz, J. / Laulumaa, S. / Fraikin, P. / de Tullio, P. / Beaufour, C. / Botez, I. / Pickering, D.S. / Frydenvang, K. / Danober, L. / Kristensen, A.S. / Kastrup, J.S. / Pirotte, B. |
External links | Eur. J. Med. Chem. / PubMed:38101041 |
Methods | X-ray diffraction |
Resolution | 1.55 Å |
Structure data | PDB-8qez: |
Chemicals | ChemComp-GLU: ChemComp-ZN: ChemComp-ACT: ChemComp-UF5: ChemComp-CL: ChemComp-GOL: ChemComp-CAC: ChemComp-HOH: |
Source |
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Keywords | MEMBRANE PROTEIN / AMPA RECEPTOR LIGAND-BINDING DOMAIN / GLUA2 S1S2J-L504Y-N775S / BPAM395 / POSITIVE ALLOSTERIC MODULATION |