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Structure paper

TitleHIF prolyl hydroxylase 2 in complex with HIF2alpha-CODD
Journal, issue, pagesTo Be Published
Publish dateAug 9, 2023 (structure data deposition date)
AuthorsFiorini, G. / Figg Jr, W.D. / Schofield, C.J.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution1.36 - 1.49 Å
Structure data

PDB-8q5s:
Anaerobic crystal structure of apo-HIF prolyl hydroxylase 2 (PHD2 181-407)in complex with acetate (ACT) and HIF2alpha-CODD peptide
Method: X-RAY DIFFRACTION / Resolution: 1.49 Å

PDB-8q64:
Crystal structure of hydroxylated HIF2alpha-CODD peptide (523-542) bound to apo-HIF prolyl hydroxylase 2 (PHD2 181-407)
Method: X-RAY DIFFRACTION / Resolution: 1.36 Å

PDB-8q6d:
Anaerobic crystal structure of HIF prolyl hydroxylase 2 (PHD2 181-407) in complex with HIF2alpha-CODD peptide (523-542), Fe(II) and 2-oxoglutarate (2OG)
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

PDB-8q6e:
Aerobic crystal structure of HIF prolyl hydroxylase 2 (PHD2 181-407) in complex with Fe(III), 2-oxoglutarate (2OG) and HIF2alpha-CODD peptide
Method: X-RAY DIFFRACTION / Resolution: 1.37 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-FE:
Unknown entry

ChemComp-AKG:
2-OXOGLUTARIC ACID

ChemComp-MG:
Unknown entry

ChemComp-CL:
Unknown entry

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / 2OG oxygenases / oxygen sensor / jelly-roll

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