+Search query
-Structure paper
Title | Structure-Guided Design of a Domain-Selective Bromodomain and Extra Terminal N-Terminal Bromodomain Chemical Probe. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 66, Page 15728-15749, Year 2023 |
Publish date | Jul 22, 2023 (structure data deposition date) |
Authors | Bradley, E. / Fusani, L. / Chung, C.W. / Craggs, P.D. / Demont, E.H. / Humphreys, P.G. / Mitchell, D.J. / Phillipou, A. / Rioja, I. / Shah, R.R. ...Bradley, E. / Fusani, L. / Chung, C.W. / Craggs, P.D. / Demont, E.H. / Humphreys, P.G. / Mitchell, D.J. / Phillipou, A. / Rioja, I. / Shah, R.R. / Wellaway, C.R. / Prinjha, R.K. / Palmer, D.S. / Kerr, W.J. / Reid, M. / Wall, I.D. / Cookson, R. |
External links | J. Med. Chem. / PubMed:37967462 |
Methods | X-ray diffraction |
Resolution | 1.3 - 1.622 Å |
Structure data | PDB-8px2: PDB-8px8: PDB-8pxa: |
Chemicals | ChemComp-NUB: ChemComp-MES: ChemComp-HOH: ChemComp-EDO: ChemComp-I0U: ChemComp-I0Z: |
Source |
|
Keywords | TRANSCRIPTION / Bromodomain inhibitor / complex / INHIBITOR / HISTONE / EPIGENETIC READER / BROMODOMAIN / BRD4 / BROMODOMAIN CONTAINING PROTEIN 4 / ANTAGONIST |