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-Structure paper
Title | N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1. |
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Journal, issue, pages | Angew. Chem. Int. Ed. Engl., Vol. 63, Page e202318849-e202318849, Year 2024 |
Publish date | Jul 10, 2023 (structure data deposition date) |
Authors | Schmidt, M. / Grethe, C. / Recknagel, S. / Kipka, G.M. / Klink, N. / Gersch, M. |
External links | Angew. Chem. Int. Ed. Engl. / PubMed:38239128 |
Methods | X-ray diffraction |
Resolution | 1.48 - 2.2 Å |
Structure data | PDB-8ppw: PDB-8pq0: PDB-8pw1: |
Chemicals | ChemComp-86F: ChemComp-HOH: ChemComp-8RX: ChemComp-GKO: |
Source |
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Keywords | HYDROLASE / Parkinson disease protein 7 / cyanopyrrolidine / DJ-1 / DUB / Deubiquitinase / UCHL1 / UCH-L1 / Ubiquitin / nitrile / covalent / cyanopiperazine |