+Search query
-Structure paper
Title | Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings. |
---|---|
Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 95, Page 129488-129488, Year 2023 |
Publish date | May 15, 2023 (structure data deposition date) |
![]() | Fnaiche, A. / Melin, L. / Suarez, N.G. / Paquin, A. / Vu, V. / Li, F. / Allali-Hassani, A. / Bolotokova, A. / Allemand, F. / Gelin, M. ...Fnaiche, A. / Melin, L. / Suarez, N.G. / Paquin, A. / Vu, V. / Li, F. / Allali-Hassani, A. / Bolotokova, A. / Allemand, F. / Gelin, M. / Cotelle, P. / Woo, S. / LaPlante, S.R. / Barsyte-Lovejoy, D. / Santhakumar, V. / Vedadi, M. / Guichou, J.F. / Annabi, B. / Gagnon, A. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.95 - 2.45 Å |
Structure data | ![]() PDB-8p29: ![]() PDB-8poj: ![]() PDB-8pom: ![]() PDB-8pon: |
Chemicals | ![]() ChemComp-MYR: ![]() ChemComp-GOL: ![]() ChemComp-WJC: ![]() ChemComp-HOH: ![]() ChemComp-ZUL: ![]() ChemComp-ZUP: ![]() ChemComp-ZUT: |
Source |
|
![]() | SIGNALING PROTEIN / Inhibitor / TEAD / Complex |