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-Structure paper
| Title | Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers. |
|---|---|
| Journal, issue, pages | Nature, Vol. 629, Page 443-449, Year 2024 |
| Publish date | Jun 16, 2023 (structure data deposition date) |
 Authors | Ferretti, S. / Hamon, J. / de Kanter, R. / Scheufler, C. / Andraos-Rey, R. / Barbe, S. / Bechter, E. / Blank, J. / Bordas, V. / Dammassa, E. ...Ferretti, S. / Hamon, J. / de Kanter, R. / Scheufler, C. / Andraos-Rey, R. / Barbe, S. / Bechter, E. / Blank, J. / Bordas, V. / Dammassa, E. / Decker, A. / Di Nanni, N. / Dourdoigne, M. / Gavioli, E. / Hattenberger, M. / Heuser, A. / Hemmerlin, C. / Hinrichs, J. / Kerr, G. / Laborde, L. / Jaco, I. / Nunez, E.J. / Martus, H.J. / Quadt, C. / Reschke, M. / Romanet, V. / Schaeffer, F. / Schoepfer, J. / Schrapp, M. / Strang, R. / Voshol, H. / Wartmann, M. / Welly, S. / Zecri, F. / Hofmann, F. / Mobitz, H. / Cortes-Cros, M. |
 External links | Nature / PubMed:38658754 |
| Methods | X-ray diffraction |
| Resolution | 1.6 - 1.9 Å |
| Structure data |  PDB-8pfl:  PDB-8pfo:  PDB-8pfp: |
| Chemicals |  ChemComp-ZN: 
ChemComp-YH8:  ChemComp-HOH:
ChemComp-YHC:  ChemComp-AGS: |
| Source |
|
 Keywords | HYDROLASE / Inhibitor / Complex |
homo sapiens (human)