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TitleThe reversible inhibitor SR-4835 binds Cdk12/cyclin K in a noncanonical G-loop conformation.
Journal, issue, pagesJ. Biol. Chem., Vol. 300, Page 105501-105501, Year 2023
Publish dateMay 31, 2023 (structure data deposition date)
AuthorsSchmitz, M. / Kaltheuner, I.H. / Anand, K. / Duster, R. / Moecking, J. / Monastyrskyi, A. / Duckett, D.R. / Roush, W.R. / Geyer, M.
External linksJ. Biol. Chem. / PubMed:38016516
MethodsX-ray diffraction
Resolution2.68 Å
Structure data

PDB-8p81:
Crystal structure of human Cdk12/Cyclin K in complex with inhibitor SR-4835
Method: X-RAY DIFFRACTION / Resolution: 2.68 Å

Chemicals

ChemComp-RMF:
~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / Cyclin-dependent kinase / inhibitor / SR-4835 / Cdk12 / Cyclin K

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