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Structure paper

TitleCrystal structure of the human CDK7 kinase domain in complex with LDC4297
Journal, issue, pagesTo Be Published
Publish dateMay 23, 2023 (structure data deposition date)
AuthorsLaursen, M. / Caing-Carlsson, R. / Houssari, R. / Javadi, A. / Kimbung, Y.R. / Murina, V. / Orozco-Rodriguez, J.M. / Svensson, A. / Welin, M. / Logan, D. ...Laursen, M. / Caing-Carlsson, R. / Houssari, R. / Javadi, A. / Kimbung, Y.R. / Murina, V. / Orozco-Rodriguez, J.M. / Svensson, A. / Welin, M. / Logan, D. / Svensson, B. / Walse, B.
External linksSearch PubMed
MethodsX-ray diffraction
Resolution2.75 Å
Structure data

PDB-8p4z:
Crystal structure of the human CDK7 kinase domain in complex with LDC4297
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-WZ8:
2-[(3R)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine

ChemComp-GOL:
GLYCEROL

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-1PE:
PENTAETHYLENE GLYCOL / precipitant*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCELL CYCLE / transferase / cyclin-dependent kinase / cell division

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