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-Structure paper
Title | Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 8782-8807, Year 2023 |
Publish date | Apr 24, 2023 (structure data deposition date) |
![]() | Michaelides, I.N. / Collie, G.W. / Borjesson, U. / Vasalou, C. / Alkhatib, O. / Barlind, L. / Cheung, T. / Dale, I.L. / Embrey, K.J. / Hennessy, E.J. ...Michaelides, I.N. / Collie, G.W. / Borjesson, U. / Vasalou, C. / Alkhatib, O. / Barlind, L. / Cheung, T. / Dale, I.L. / Embrey, K.J. / Hennessy, E.J. / Khurana, P. / Koh, C.M. / Lamb, M.L. / Liu, J. / Moss, T.A. / O'Neill, D.J. / Phillips, C. / Shaw, J. / Snijder, A. / Storer, R.I. / Stubbs, C.J. / Han, F. / Li, C. / Qiao, J. / Sun, D.Q. / Wang, J. / Wang, P. / Yang, W. |
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Methods | X-ray diffraction |
Resolution | 1.77 - 2.631 Å |
Structure data | ![]() PDB-8ouu: ![]() PDB-8ouv: ![]() PDB-8ov7: ![]() PDB-8ovz: ![]() PDB-8ow3: ![]() PDB-8owg: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-EDO: ![]() ChemComp-FMT: ![]() ChemComp-W49: ![]() ChemComp-HOH: ![]() ChemComp-W3R: ![]() ChemComp-CL: ![]() ChemComp-W3W: ![]() ChemComp-IOD: ![]() ChemComp-W3N: ![]() ChemComp-W40: |
Source |
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![]() | TRANSFERASE / kinase / inhibitor / cancer research / drug discovery |