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Title4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.
Journal, issue, pagesMol. Cancer Ther., Vol. 23, Page 683-699, Year 2024
Publish dateApr 5, 2023 (structure data deposition date)
AuthorsCalbert, M.L. / Chandramouly, G. / Adams, C.M. / Saez-Ayala, M. / Kent, T. / Tyagi, M. / Ayyadevara, V.S.S.A. / Wang, Y. / Krais, J.J. / Gordon, J. ...Calbert, M.L. / Chandramouly, G. / Adams, C.M. / Saez-Ayala, M. / Kent, T. / Tyagi, M. / Ayyadevara, V.S.S.A. / Wang, Y. / Krais, J.J. / Gordon, J. / Atkins, J. / Toma, M.M. / Betzi, S. / Boghossian, A.S. / Rees, M.G. / Ronan, M.M. / Roth, J.A. / Goldman, A.R. / Gorman, N. / Mitra, R. / Childers, W.E. / Grana, X. / Skorski, T. / Johnson, N. / Hurtz, C. / Morelli, X. / Eischen, C.M. / Pomerantz, R.T.
External linksMol. Cancer Ther. / PubMed:38064712
MethodsX-ray diffraction
Resolution2.1 Å
Structure data

PDB-8ooj:
Crystal structure of dCK C4S-S74E mutant in complex with EdC and UDP
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-UDP:
URIDINE-5'-DIPHOSPHATE / UDP*YM

ChemComp-VVC:
4-azanyl-1-[(2~{R},4~{S},5~{R})-5-ethynyl-5-(hydroxymethyl)-4-oxidanyl-oxolan-2-yl]pyrimidin-2-one

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Nucleoside kinase / phosphorylation / complex

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