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TitleThe discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents.
Journal, issue, pagesEur. J. Med. Chem., Vol. 264, Page 115946-115946, Year 2023
Publish dateMar 13, 2023 (structure data deposition date)
AuthorsLinciano, P. / Pozzi, C. / Tassone, G. / Landi, G. / Mangani, S. / Santucci, M. / Luciani, R. / Ferrari, S. / Santarem, N. / Tagliazucchi, L. ...Linciano, P. / Pozzi, C. / Tassone, G. / Landi, G. / Mangani, S. / Santucci, M. / Luciani, R. / Ferrari, S. / Santarem, N. / Tagliazucchi, L. / Cordeiro-da-Silva, A. / Tonelli, M. / Tondi, D. / Bertarini, L. / Gul, S. / Witt, G. / Moraes, C.B. / Costantino, L. / Costi, M.P.
External linksEur. J. Med. Chem. / PubMed:38043491
MethodsX-ray diffraction
Resolution1.48 Å
Structure data

PDB-8of2:
Trypanosoma brucei pteridine reductase 1 (TbPTR1) in complex with 2,4,6 triamminopyrimidine (TAP)
Method: X-RAY DIFFRACTION / Resolution: 1.48 Å

Chemicals

ChemComp-3AY:
PYRIMIDINE-2,4,6-TRIAMINE

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • trypanosoma brucei brucei (eukaryote)
KeywordsOXIDOREDUCTASE / Trypanosoma brucei / pteridine reductase / PTR1 / TbPTR1 / triamminopyrimidine

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