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Structure paper

TitleDiscovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.
Journal, issue, pagesJ. Med. Chem., Vol. 67, Page 2667-2689, Year 2024
Publish dateAug 21, 2023 (structure data deposition date)
AuthorsYang, F. / Lin, Q. / Song, X. / Huang, H. / Chen, X. / Tan, J. / Li, Y. / Zhou, Y. / Tu, Z. / Du, H. ...Yang, F. / Lin, Q. / Song, X. / Huang, H. / Chen, X. / Tan, J. / Li, Y. / Zhou, Y. / Tu, Z. / Du, H. / Zhang, Z.M. / Ortega, R. / Lin, X. / Patterson, A.V. / Smaill, J.B. / Chen, Y. / Lu, X.
External linksJ. Med. Chem. / PubMed:38348819
MethodsX-ray diffraction
Resolution1.42 - 2.3 Å
Structure data

PDB-8kh6:
Crystal structure of FGFR4 kinase domain with 8r
Method: X-RAY DIFFRACTION / Resolution: 1.62 Å

PDB-8kh7:
Crystal structure of FGFR4 kinase domain with 8zc
Method: X-RAY DIFFRACTION / Resolution: 1.52 Å

PDB-8kh8:
Crystal structure of FGFR4(V550L) kinase domain with 8z
Method: X-RAY DIFFRACTION / Resolution: 1.49 Å

PDB-8kh9:
Crystal structure of FGFR4(V550M) kinase domain with 8z
Method: X-RAY DIFFRACTION / Resolution: 1.42 Å

PDB-8w5c:
Crystal structure of FGFR4 kinase domain in complex with 8K
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-SO4:
SULFATE ION


ChemComp, No image

ChemComp-VVI:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER


ChemComp, No image

ChemComp-VVW:
Unknown entry


ChemComp, No image

ChemComp-VZO:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/INHIBITOR / complex / TRANSFERASE / TRANSFERASE-INHIBITOR complex / FGFR4 kinase domain / inhibitor / FGFR4

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