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TitleDiscovery of 1 H -Imidazo[4,5- b ]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain.
Journal, issue, pagesJ. Med. Chem., Vol. 66, Page 8725-8744, Year 2023
Publish dateFeb 10, 2023 (structure data deposition date)
AuthorsChen, X. / Cao, D. / Liu, C. / Meng, F. / Zhang, Z. / Xu, R. / Tong, Y. / Xin, Y. / Zhang, W. / Kang, W. ...Chen, X. / Cao, D. / Liu, C. / Meng, F. / Zhang, Z. / Xu, R. / Tong, Y. / Xin, Y. / Zhang, W. / Kang, W. / Bao, Q. / Shen, J. / Xiong, B. / You, Q. / Jiang, Z.
External linksJ. Med. Chem. / PubMed:37382379
MethodsX-ray diffraction
Resolution1.45 - 1.57 Å
Structure data

PDB-8ibq:
Bromodomain and Extra-terminal Domain (BET) BRD4
Method: X-RAY DIFFRACTION / Resolution: 1.45 Å

PDB-8idh:
Bromodomain and Extra-terminal Domain (BET) BRD4
Method: X-RAY DIFFRACTION / Resolution: 1.57 Å

Chemicals

ChemComp-OWO:
7-[2-fluoranyl-3-(1,3,5-trimethylpyrazol-4-yl)phenyl]-1~{H}-imidazo[4,5-b]pyridine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / binds acetylated lysine residues

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