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-Structure paper
Title | Discovery of TP0597850: A Selective, Chemically Stable, and Slow Tight-Binding Matrix Metalloproteinase-2 Inhibitor with a Phenylbenzamide-Pentapeptide Hybrid Scaffold. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 822-836, Year 2023 |
Publish date | Oct 19, 2022 (structure data deposition date) |
Authors | Takeuchi, T. / Nomura, Y. / Tamita, T. / Nishikawa, R. / Kakinuma, H. / Kojima, N. / Hitaka, K. / Tamura, Y. / Kamitani, M. / Mima, M. ...Takeuchi, T. / Nomura, Y. / Tamita, T. / Nishikawa, R. / Kakinuma, H. / Kojima, N. / Hitaka, K. / Tamura, Y. / Kamitani, M. / Mima, M. / Nozoe, A. / Hayashi, M. |
External links | J. Med. Chem. / PubMed:36595440 |
Methods | X-ray diffraction |
Resolution | 2.4 Å |
Structure data | PDB-8h78: |
Chemicals | ChemComp-ZN: ChemComp-CA: ChemComp-2HP: ChemComp-L2U: ChemComp-HOH: |
Source |
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Keywords | HYDROLASE / Gelatinase A / Matrix metalloproteinase-2 / 72 kDa type IV collagenase |