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Structure paper

TitleThe co-crystal structure of Cbl-b and a small-molecule inhibitor reveals the mechanism of Cbl-b inhibition.
Journal, issue, pagesCommun Biol, Vol. 6, Page 1272-1272, Year 2023
Publish dateMar 3, 2023 (structure data deposition date)
AuthorsKimani, S.W. / Perveen, S. / Szewezyk, M. / Zeng, H. / Dong, A. / Li, F. / Ghiabi, P. / Li, Y. / Chau, I. / Arrowsmith, C.H. ...Kimani, S.W. / Perveen, S. / Szewezyk, M. / Zeng, H. / Dong, A. / Li, F. / Ghiabi, P. / Li, Y. / Chau, I. / Arrowsmith, C.H. / Barsyte-Lovejoy, D. / Santhakumar, V. / Vedadi, M. / Halabelian, L.
External linksCommun Biol / PubMed:38104184
MethodsX-ray diffraction
Resolution1.81 Å
Structure data

PDB-8gcy:
Co-crystal structure of CBL-B in complex with N-Aryl isoindolin-1-one inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.81 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-Z3N:
2-{3-[(1s,3R)-3-methyl-1-(4-methyl-4H-1,2,4-triazol-3-yl)cyclobutyl]phenyl}-6-{[(3S)-3-methylpiperidin-1-yl]methyl}-4-(trifluoromethyl)-2,3-dihydro-1H-isoindol-1-one

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

ChemComp-UNX:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE/LIGASE INHIBITOR / E3 ligase / CBL-B / inhibitor / SGC / LIGASE / LIGASE-LIGASE INHIBITOR complex

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