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-Structure paper
| Title | Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127. |
|---|---|
| Journal, issue, pages | Science, Vol. 383, Page eadi5798-eadi5798, Year 2024 |
| Publish date | Mar 1, 2023 (structure data deposition date) |
 Authors | Montoya, S. / Bourcier, J. / Noviski, M. / Lu, H. / Thompson, M.C. / Chirino, A. / Jahn, J. / Sondhi, A.K. / Gajewski, S. / Tan, Y.S.M. ...Montoya, S. / Bourcier, J. / Noviski, M. / Lu, H. / Thompson, M.C. / Chirino, A. / Jahn, J. / Sondhi, A.K. / Gajewski, S. / Tan, Y.S.M. / Yung, S. / Urban, A. / Wang, E. / Han, C. / Mi, X. / Kim, W.J. / Sievers, Q. / Auger, P. / Bousquet, H. / Brathaban, N. / Bravo, B. / Gessner, M. / Guiducci, C. / Iuliano, J.N. / Kane, T. / Mukerji, R. / Reddy, P.J. / Powers, J. / Sanchez Garcia de Los Rios, M. / Ye, J. / Barrientos Risso, C. / Tsai, D. / Pardo, G. / Notti, R.Q. / Pardo, A. / Affer, M. / Nawaratne, V. / Totiger, T.M. / Pena-Velasquez, C. / Rhodes, J.M. / Zelenetz, A.D. / Alencar, A. / Roeker, L.E. / Mehta, S. / Garippa, R. / Linley, A. / Soni, R.K. / Skanland, S.S. / Brown, R.J. / Mato, A.R. / Hansen, G.M. / Abdel-Wahab, O. / Taylor, J. |
 External links | Science / PubMed:38301010 |
| Methods | X-ray diffraction |
| Resolution | 1.75 - 1.9 Å |
| Structure data |  PDB-8gc7:  PDB-8gc8: |
| Chemicals |  ChemComp-YXJ:  ChemComp-EDO:  ChemComp-CL:  ChemComp-HOH: |
| Source |
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 Keywords | SIGNALING PROTEIN / degrader / complex |
homo sapiens (human)