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TitleBroadly neutralizing antibodies against sarbecoviruses generated by immunization of macaques with an AS03-adjuvanted COVID-19 vaccine.
Journal, issue, pagesSci Transl Med, Vol. 15, Page eadg7404-eadg7404, Year 2023
Publish dateFeb 24, 2023 (structure data deposition date)
AuthorsFeng, Y. / Yuan, M. / Powers, J.M. / Hu, M. / Munt, J.E. / Arunachalam, P.S. / Leist, S.R. / Bellusci, L. / Kim, J. / Sprouse, K.R. ...Feng, Y. / Yuan, M. / Powers, J.M. / Hu, M. / Munt, J.E. / Arunachalam, P.S. / Leist, S.R. / Bellusci, L. / Kim, J. / Sprouse, K.R. / Adams, L.E. / Sundaramurthy, S. / Zhu, X. / Shirreff, L.M. / Mallory, M.L. / Scobey, T.D. / Moreno, A. / O'Hagan, D.T. / Kleanthous, H. / Villinger, F.J. / Veesler, D. / King, N.P. / Suthar, M.S. / Khurana, S. / Baric, R.S. / Wilson, I.A. / Pulendran, B.
External linksSci Transl Med / PubMed:37163615
MethodsX-ray diffraction
Resolution1.75 - 3.35 Å
Structure data

PDB-8gb5:
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 25F9
Method: X-RAY DIFFRACTION / Resolution: 3.35 Å

PDB-8gb6:
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 21B6
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-8gb7:
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing antibody 20A7
Method: X-RAY DIFFRACTION / Resolution: 2.57 Å

PDB-8gb8:
Crystal structure of SARS-CoV-2 BA.2 receptor binding domain in complex with neutralizing antibody 20A7
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-BCN:
BICINE / pH buffer*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GLY:
GLYCINE

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • severe acute respiratory syndrome coronavirus 2
  • macaca mulatta (Rhesus monkey)
KeywordsIMMUNE SYSTEM / COVID-19 / SARS-CoV-2 / antibody / spike / receptor binding domain

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