Database of articles cited by EMDB/PDB/SASBDB data

Keywords
Structure methods	All X-ray diffraction NMR electron microscopy small angle scattering neutron diffraction fiber diffraction powder diffraction infrared spectroscopy EPR fluorescence transfer theoretical model Hybrid
Author
Journal
IF	>30 >20 >10 >5 all

Title	A pan-influenza antibody inhibiting neuraminidase via receptor mimicry.
Journal, issue, pages	Nature, Vol. 618, Issue 7965, Page 590-597, Year 2023
Publish date	May 31, 2023
Authors	Corey Momont / Ha V Dang / Fabrizia Zatta / Kevin Hauser / Caihong Wang / Julia di Iulio / Andrea Minola / Nadine Czudnochowski / Anna De Marco / Kaitlin Branch / David Donermeyer / Siddhant Vyas / Alex Chen / Elena Ferri / Barbara Guarino / Abigail E Powell / Roberto Spreafico / Samantha S Yim / Dale R Balce / Istvan Bartha / Marcel Meury / Tristan I Croll / David M Belnap / Michael A Schmid / William Timothy Schaiff / Jessica L Miller / Elisabetta Cameroni / Amalio Telenti / Herbert W Virgin / Laura E Rosen / Lisa A Purcell / Antonio Lanzavecchia / Gyorgy Snell / Davide Corti / Matteo Samuele Pizzuto /
PubMed Abstract	Rapidly evolving influenza A viruses (IAVs) and influenza B viruses (IBVs) are major causes of recurrent lower respiratory tract infections. Current influenza vaccines elicit antibodies ...Rapidly evolving influenza A viruses (IAVs) and influenza B viruses (IBVs) are major causes of recurrent lower respiratory tract infections. Current influenza vaccines elicit antibodies predominantly to the highly variable head region of haemagglutinin and their effectiveness is limited by viral drift and suboptimal immune responses. Here we describe a neuraminidase-targeting monoclonal antibody, FNI9, that potently inhibits the enzymatic activity of all group 1 and group 2 IAVs, as well as Victoria/2/87-like, Yamagata/16/88-like and ancestral IBVs. FNI9 broadly neutralizes seasonal IAVs and IBVs, including the immune-evading H3N2 strains bearing an N-glycan at position 245, and shows synergistic activity when combined with anti-haemagglutinin stem-directed antibodies. Structural analysis reveals that D107 in the FNI9 heavy chain complementarity-determinant region 3 mimics the interaction of the sialic acid carboxyl group with the three highly conserved arginine residues (R118, R292 and R371) of the neuraminidase catalytic site. FNI9 demonstrates potent prophylactic activity against lethal IAV and IBV infections in mice. The unprecedented breadth and potency of the FNI9 monoclonal antibody supports its development for the prevention of influenza illness by seasonal and pandemic viruses.
External links	Nature / PubMed:37258672 / PubMed Central
Methods	EM (single particle)
Resolution	2.2 - 3.1 Å
Structure data	29686 8g30 EMDB-29686, PDB-8g30: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI19 Fab molecules Method: EM (single particle) / Resolution: 3.1 Å 29704 8g3m EMDB-29704, PDB-8g3m: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 3 FNI9 Fab molecules Method: EM (single particle) / Resolution: 3.0 Å 29705 8g3n EMDB-29705, PDB-8g3n: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 4 FNI9 Fab molecules Method: EM (single particle) / Resolution: 2.9 Å 29706 8g3o EMDB-29706, PDB-8g3o: N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 3 FNI9 Fab molecules Method: EM (single particle) / Resolution: 3.1 Å 29707 8g3p EMDB-29707, PDB-8g3p: N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI9 Fab molecules Method: EM (single particle) / Resolution: 2.5 Å 29708 8g3q EMDB-29708, PDB-8g3q: N2 neuraminidase of A/Tanzania/205/2010 H3N2 in complex with 3 FNI17 Fab molecules Method: EM (single particle) / Resolution: 2.3 Å 29709 8g3r EMDB-29709, PDB-8g3r: N2 neuraminidase of A/Tanzania/205/2010 H3N2 with S245N S247T mutations in complex with one FNI17 Fab molecule Method: EM (single particle) / Resolution: 2.3 Å 29710 8g3v EMDB-29710, PDB-8g3v: N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 4 FNI19 Fab molecules Method: EM (single particle) / Resolution: 2.2 Å 29711 8g3z EMDB-29711, PDB-8g3z: Neuraminidase of B/Massachusetts/02/2012 (Yamagata) in complex with 4 FNI17 Fab molecules Method: EM (single particle) / Resolution: 2.3 Å 29712 8g40 EMDB-29712, PDB-8g40: N2 neuraminidase of A/Hong_Kong/2671/2019 in complex with 3 FNI19 Fab molecules Method: EM (single particle) / Resolution: 2.8 Å
Chemicals	ChemComp-CA: Unknown entry ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose
Source	influenza a virus homo sapiens (human) influenza b virus
Keywords	VIRAL PROTEIN/IMMUNE SYSTEM / viral glycoprotein / antibody / Fab / influenza / virus / VIRAL PROTEIN-IMMUNE SYSTEM complex