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Title | Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 14787-14814, Year 2023 |
Publish date | Feb 3, 2023 (structure data deposition date) |
Authors | Sinatra, L. / Vogelmann, A. / Friedrich, F. / Tararina, M.A. / Neuwirt, E. / Colcerasa, A. / Konig, P. / Toy, L. / Yesiloglu, T.Z. / Hilscher, S. ...Sinatra, L. / Vogelmann, A. / Friedrich, F. / Tararina, M.A. / Neuwirt, E. / Colcerasa, A. / Konig, P. / Toy, L. / Yesiloglu, T.Z. / Hilscher, S. / Gaitzsch, L. / Papenkordt, N. / Zhai, S. / Zhang, L. / Romier, C. / Einsle, O. / Sippl, W. / Schutkowski, M. / Gross, O. / Bendas, G. / Christianson, D.W. / Hansen, F.K. / Jung, M. / Schiedel, M. |
External links | J. Med. Chem. / PubMed:37902787 |
Methods | X-ray diffraction |
Resolution | 1.65 - 1.87 Å |
Structure data | PDB-8g1z: PDB-8g20: PDB-8owz: |
Chemicals | ChemComp-YIZ: ChemComp-ZN: ChemComp-K: ChemComp-EDO: ChemComp-HOH: ChemComp-YJ5: ChemComp-EOH: ChemComp-KZU: ChemComp-BTB: ChemComp-BU3: ChemComp-CL: |
Source |
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Keywords | HYDROLASE/INHIBITOR / histone deacetylase / inhibitor / metallohydrolase / hydrolase-inhibitor complex / HYDROLASE / Sirtuin 2 |