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Structure paper

TitleAffinity and cooperativity modulate ternary complex formation to drive targeted protein degradation.
Journal, issue, pagesNat Commun, Vol. 14, Page 4177-4177, Year 2023
Publish dateFeb 2, 2023 (structure data deposition date)
AuthorsWurz, R.P. / Rui, H. / Dellamaggiore, K. / Ghimire-Rijal, S. / Choi, K. / Smither, K. / Amegadzie, A. / Chen, N. / Li, X. / Banerjee, A. ...Wurz, R.P. / Rui, H. / Dellamaggiore, K. / Ghimire-Rijal, S. / Choi, K. / Smither, K. / Amegadzie, A. / Chen, N. / Li, X. / Banerjee, A. / Chen, Q. / Mohl, D. / Vaish, A.
External linksNat Commun / PubMed:37443112
MethodsX-ray diffraction
Resolution2.7 - 3.73 Å
Structure data

PDB-8g1p:
Co-crystal structure of Compound 11 in complex with the bromodomain of human SMARCA2 and pVHL:ElonginC:ElonginB
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-8g1q:
Co-crystal structure of Compound 1 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB
Method: X-RAY DIFFRACTION / Resolution: 3.73 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-FWZ:
(2~{S},4~{R})-~{N}-[[2-[2-[4-[[4-[3-azanyl-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl]methyl]phenyl]ethoxy]-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{S})-2-[(1-fluoranylcyclopropyl)carbonylamino]-3,3-dimethyl-butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide

ChemComp-HOH:
WATER

ChemComp-NA:
Unknown entry

ChemComp-YHB:
N-(2-{4-[(6M)-3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]piperazin-1-yl}pyridine-4-carbonyl)-3-methyl-L-valyl-(4R)-4-hydroxy-N-{(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl}-L-prolinamide

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / Ternary Complex / PROTACs / TRANSCRIPTION

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