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Structure paper

TitleA specialized integrin-binding motif enables proTGF-beta 2 activation by integrin alpha V beta 6 but not alpha V beta 8.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 120, Page e2304874120-e2304874120, Year 2023
Publish dateJan 25, 2023 (structure data deposition date)
AuthorsLe, V.Q. / Zhao, B. / Ramesh, S. / Toohey, C. / DeCosta, A. / Mintseris, J. / Liu, X. / Gygi, S. / Springer, T.A.
External linksProc. Natl. Acad. Sci. USA / PubMed:37279271
MethodsX-ray diffraction
Resolution2.2 - 3.15 Å
Structure data

PDB-8fxs:
Crystal structure of human pro-TGF-beta2 in complex with Nb9
Method: X-RAY DIFFRACTION / Resolution: 3.15 Å

PDB-8fxv:
Crystal structure of human proTGF-beta2 in complex with Nb18
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsCYTOKINE / TGF-b TGF-beta nanobody latent procomplex prodomain

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