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Structure paper

TitleStructures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.
Journal, issue, pagesPlos Pathog., Vol. 19, Page e1011546-e1011546, Year 2023
Publish dateJan 7, 2023 (structure data deposition date)
AuthorsKottur, J. / White, K.M. / Rodriguez, M.L. / Rechkoblit, O. / Quintana-Feliciano, R. / Nayar, A. / Garcia-Sastre, A. / Aggarwal, A.K.
External linksPlos Pathog. / PubMed:37523415
MethodsX-ray diffraction
Resolution1.57 - 1.61 Å
Structure data

PDB-8frj:
Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC0946
Method: X-RAY DIFFRACTION / Resolution: 1.57 Å

PDB-8frk:
Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC8158
Method: X-RAY DIFFRACTION / Resolution: 1.61 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-AW2:
5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine

ChemComp-HOH:
WATER

ChemComp-EOH:
ETHANOL

ChemComp-MJ7:
5'-S-(4-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}butyl)-5'-thioadenosine

ChemComp-K:
Unknown entry

Source
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN / N7-guanine methyl transferase / SARS-CoV-2 / nsp14

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