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-Structure paper
Title | Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding. |
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Journal, issue, pages | Nat Commun, Vol. 14, Page 3213-3213, Year 2023 |
Publish date | Aug 19, 2021 (structure data deposition date) |
Authors | Faber, E.B. / Sun, L. / Tang, J. / Roberts, E. / Ganeshkumar, S. / Wang, N. / Rasmussen, D. / Majumdar, A. / Hirsch, L.E. / John, K. ...Faber, E.B. / Sun, L. / Tang, J. / Roberts, E. / Ganeshkumar, S. / Wang, N. / Rasmussen, D. / Majumdar, A. / Hirsch, L.E. / John, K. / Yang, A. / Khalid, H. / Hawkinson, J.E. / Levinson, N.M. / Chennathukuzhi, V. / Harki, D.A. / Schonbrunn, E. / Georg, G.I. |
External links | Nat Commun / PubMed:37270540 |
Methods | X-ray diffraction |
Resolution | 1.5 - 2 Å |
Structure data | PDB-7rwf: PDB-7s84: PDB-8fow: PDB-8fp0: PDB-8fp5: |
Chemicals | ChemComp-EDO: ChemComp-7TW: ChemComp-HOH: ChemComp-8IL: ChemComp-1QK: ChemComp-RRC: ChemComp-ATP: ChemComp-MG: |
Source |
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Keywords | CELL CYCLE / Serine/threonine-protein kinase DNA repair Meiosis allosteric inhibitor drug development / allosteric inhibitor / drug development / kinase / Transferase / allosteric / inhibitor |