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Structure paper

TitleStructure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A.
Journal, issue, pagesNat Commun, Vol. 14, Page 6382-6382, Year 2023
Publish dateDec 16, 2022 (structure data deposition date)
AuthorsHarjes, S. / Kurup, H.M. / Rieffer, A.E. / Bayarjargal, M. / Filitcheva, J. / Su, Y. / Hale, T.K. / Filichev, V.V. / Harjes, E. / Harris, R.S. / Jameson, G.B.
External linksNat Commun / PubMed:37821454
MethodsX-ray diffraction
Resolution1.912 - 2.94 Å
Structure data

PDB-8fii:
Wild type APOBEC3A in complex with TT(FdZ)-hairpin inhibitor (crystal form 1)
Method: X-RAY DIFFRACTION / Resolution: 2.94 Å

PDB-8fij:
Wild type APOBEC3A in complex with TT(FdZ)-hairpin inhibitor (crystal form 2)
Method: X-RAY DIFFRACTION / Resolution: 2.799 Å

PDB-8fik:
APOBEC3A E72A inactive mutant in complex with ATTC-hairpin DNA substrate
Method: X-RAY DIFFRACTION / Resolution: 1.912 Å

PDB-8fil:
Zinc-free APOBEC3A (inactive E72A mutant) in complex with TTC-hairpin DNA substrate
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

PDB-8fim:
Structure of APOBEC3A (E72A inactive mutant) in complex with TTC-hairpin DNA substrate
Method: X-RAY DIFFRACTION / Resolution: 2.22 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-IHP:
INOSITOL HEXAKISPHOSPHATE

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / APOBEC / APOBEC3A / A3A / cancer / DNA / cytidine deaminase / hairpin DNA inhibitor / mutation / DNA BINDING PROTEIN/DNA / hairpin DNA / DNA BINDING PROTEIN-DNA complex / APOBEC3A E72A mutant

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